It Started with a Kiss ended with odd couple Zhi Shu (Joe Cheng) and Xiang Qin (Ariel Lin) getting married in characteristically comical fashion, and the sequel picks up the story with their honeymoon and married life. Xiang Qin is as ham-fisted as ever, creating many funny situations as she learns the ropes of being a wife and tries hard to become a good nurse and work alongside her genius husband. Aspiring doctor Zhi Shu meets some obstacles at school when he encounters both academic and romantic rivals who are determined to over-rule him.As Zhi Shu and Xiang Qin struggle with their professional ambitions, they also struggle with their personal relationship. Many times, Zhi Shu's coldness and harshness drives Xiang Qin to tears and she tries to run away. Zhi Shu learns to understand and deal with his jealousy when Xiang Qin's nursing fellow student Yang Qi Tai (Figaro Ceng) becomes too close. He also tries to push Xiang Qin to higher ambition and independence. Zhi Shu soon learns to love Xiang Qin and forgive her bumbling ways, and Xiang Qin tries harder to become a better wife and nurse to her husband.
Zhi Shu and Xiang Qin are not the only ones having problems with their relationship. Xiang Qin's childhood friend Ah Jin (Jiro Wang) deals with the unwelcome affections of Christine (Larisa Bakurova), an English exchange student who latches onto him against his will. Xiang Qin's friend, Chun Mei (Petty Yang), gets pregnant by her boyfriend, Ah Bu (Aaron Yan), but his wealthy, highbrow mother is desperate to keep them apart. Zhi Shu's younger brother Yu Shu (Zhang Bo Han) deals with his own first love and their story remarkably resembles that of Zhi Shu and Xiang Qin.